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Nested cross-over designs

机译:嵌套交叉设计

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摘要

In medical research, sequences of treatments may need to be applied to subjects over a period of time. Cross-over designs, in such cases, form a useful class for application. However, there may be some additional factor of variation embedded into the subjects, or the required constraints for application of a balanced design, (which is preferred), may not always be available and the cross-over designs may need to be conducted in parts or sessions. Nested cross-over designs are required under such conditions. Some such situations are considered here and useful nested cross-over designs are constructed. Relevant theory on modeling the observations obtained from such designs is also provided.
机译:在医学研究中,可能需要在一段时间内对受试者进行一系列治疗。在这种情况下,跨接设计形成了有用的应用程序类。但是,可能会有一些其他的变化因素嵌入到主题中,或者应用平衡设计所需的约束条件(这是首选)可能并不总是可用,并且跨界设计可能需要分部分进行或会话。在这种情况下需要嵌套的交叉设计。这里考虑一些这种情况,并构造有用的嵌套交叉设计。还提供了有关从此类设计获得的观测结果建模的相关理论。

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