Design for good matching in multichannel low-noise amplifier for recording neuronal signals in modern neuroscience experiments

摘要

The paper reports on the design of a prototype 16-channel ASIC for readout of signals from live neuronal systems. Single channel comprises a low-noise amplifier and a low-frequency pass-band filter. The amplifier design optimised with respect to noise and power consumption is discussed. The design of a continuous-time high-pass filter with lower cut-off frequency as low as 20 Hz, which is suitable for realisation in a CMOS process, is presented. Special attention is paid to uniformity of analogue parameters in the multichannel IC. Channel matching is evaluated by Monte Carlo simulation. The design has been fabricated in a 0.7 μm CMOS process and measurements of basic parameters and characteristics have been performed for the prototypes. Good agreement between the simulation and measurements has been achieved for single channel parameters as well as for channel matching. The obtained results on channel matching are discussed with respect to design reliability and production yield.