Micro- and nanofabrication NMR technologies for point-of-care medical applications - A review

摘要

In recent years, significant advances in NMR system miniaturisation (e.g., electronic console, radio-frequency probe, microfluidic-based chip) utilising small footprint permanent magnets ( 2 Tesla) have been widely applied for point-of-care medical diagnostic. These include immuno-magnetic labelling-based profiling of tumour cells and biomolecules (DNA and proteins) and the label-free detection of various pathological states such as oxygenation/oxidation level of the blood, malaria screening, and rapid phenotyping of diabetes mellitus. In this contribution we discuss the impact of micro- and nanofabrication technologies and system integration on the miniaturisation of NMR technologies, and the recent advances in NMR-based point-of-care medical diagnosis.