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Aptamer-modified CuS nanocrystals/graphene oxide composites for controlled release of glucosamine and chemo-photothermal therapy of tumor cells

机译:适体修饰的CuS纳米晶体/氧化石墨烯复合材料,用于葡萄糖胺的控制释放和肿瘤细胞的化学光热疗法

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摘要

In this paper, citrate-stabilized CuS nanocrystals were modified by NH2-terminated aptamer of carcinoembryonic antigen to fabricate aptamer-CuS complex via carbodiimide-activated coupling. Then, the complex was conjugated with graphene oxide (GO) to form aptamer-CuS/GO conjugates via p-p stacking interactions. Finally, glucosamine (Glu) was loaded into aptamer-CuS/GO conjugates to prepare aptamerCuS/GO/Glu composites. The composites enabled CEA-targeted and pH-sensitive Glu release. Under nearinfrared light irradiation at 980 nm, the composites had photothermal-accelerated release of Glu and chemo-photothermal synergistic therapy in vitro. Due to combined advantages from tumor biomarkertargeted, pH-sensitive, photothermal-accelerated drug release, as well as chemo-photothermal therapy, the composites could be developed towards multifunctional drug-delivery systems for highly efficient treatment against tumor cells. (C) 2017 Elsevier B.V.All rights reserved.
机译:在本文中,用NH 2终止的癌胚抗原适体修饰柠檬酸盐稳定的CuS纳米晶体,以通过碳二亚胺激活的偶联制备适体-CuS复合物。然后,将复合物与氧化石墨烯(GO)共轭,以通过p-p堆积相互作用形成适体-CuS / GO共轭物。最后,将葡糖胺(Glu)加载到适体-CuS / GO结合物中以制备适体CuS / GO / Glu复合材料。该复合材料可实现CEA靶向和pH敏感的Glu释放。在980 nm的近红外光照射下,该复合物具有光热促进的Glu释放和体外化学-光热协同治疗。由于肿瘤生物标志物靶向,pH敏感,光热促进药物释放以及化学光热疗法的综合优势,复合材料可以开发为多功能药物递送系统,以高效治疗肿瘤细胞。 (C)2017 Elsevier B.V.保留所有权利。

著录项

  • 来源
    《Materials Letters》 |2017年第may15期|131-135|共5页
  • 作者单位

    Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu, Peoples R China|Second Tradit Chinese Med Hosp Jiangsu Prov, Nanjing 210017, Jiangsu, Peoples R China;

    Tradit Chinese Med Hosp Kunshan, Kunshan 215300, Peoples R China;

    Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu, Peoples R China;

    Second Tradit Chinese Med Hosp Jiangsu Prov, Nanjing 210017, Jiangsu, Peoples R China;

    Qingdao Univ, Coll Chem & Chem Engn, Qingdao 266071, Peoples R China;

    Second Tradit Chinese Med Hosp Jiangsu Prov, Nanjing 210017, Jiangsu, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Graphene oxide; Composite materials; Biomaterials; Functional; Glucosamine;

    机译:氧化石墨烯;复合材料;生物材料;功能性;葡萄糖胺;

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