The influence of flow rates on the dynamic degradation behaviour of porous magnesium under a simulated environment of human cancellous bone

摘要

Abstract This study analyses the effect of different flow rates on the degradation behaviour of porous magnesium for bone scaffold applications. A simulated boundary of bone marrow movement induced by various physiological activities was considered with a variation in flow rate in the experimental process, also known as a dynamic immersion test. Three types of porous magnesium (30%, 41%, and 55%) were immersed in simulated body fluid (SBF) for 24, 48, and 72h. The results show that the relative weight loss and mechanical properties of the porous magnesium significantly degraded by 68% and 95%, respectively, at increasing flow rates together with an increase in immersion period and porosity. Graphical abstract Display Omitted Highlights • The mechanical loading from physiological activity induced different fluid flow of bone marrow due to pressure differentials. • The dynamic immersion tests were performed with three different flow rates of simulated body fluid. • Weight loss and mechanical properties of the porous Magnesium significantly degraded with 68% and 95%, respectively.