BASIC CONCEPT OF BONE TISSUE ENGINEERING USING CERAMIC SCAFFOLDS

摘要

Bone is a composite material composed of an organic matrix, made essentially of collagen I mineralized with a carbonate-containing calcium apatite. Two types of bone can be distinguished, cortical bone, which is constructed of ～90 percent solid bone tissue, and trabecular bone which is spongy and contains 80 percent marrow filled voids. Bone is a dynamic tissue subjected to constant remodeling, i.e., deposition by osteoblast activity and subsequent resorption by osteoclasts. Musculoskeletal conditions are among the most frequently occurring medical conditions, and they have a substantial impact on the healthy and quality of life of the population.