South Indian leprosy vaccine trial: important lessons for mycobacterial immunology

摘要

Between January 1991 and July 1993, 171,400 individuals living in Chingleput District, South India, were recruited into a major leprosy vaccine trial organized by the Indian Council For Medical Research. The participants were randomized to receive a placebo, a plain BCG Vaccine, a combination of BCG plus killed leprosy bacilli, or else a killed environmental Mycobacterial vaccine: either 'Mycobacterium W', or 'Mycobacterium ICRC'. Eighty-five Percent of these individuals were examined for leprosy between August 1993 and February 1995 and 75/100 were examined between January 1997 and September 1998.