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Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm

机译:人类恐惧增强的惊吓范例中的有条件的恐惧消灭和恢复

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摘要

The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and an airblast to the throat as the unconditioned stimulus (US). Participants were extinguished 24 h after fear conditioning. Upon presentation of unsignaled USs after extinction, participants displayed significant fear reinstatement. In summary, these procedures produced robust fear-potentiated startle, significant CS+/CS− discrimination, within-session extinction, and significant reinstatement. This is the first demonstration of fear extinction and reinstatement in humans using startle measures.
机译:这项研究的目的是使用恐惧增强的惊吓来分析人类的恐惧消灭和恢复。使用简单的辨别程序,以彩色光作为条件刺激(CSs),并向喉咙吹气作为无条件刺激(US),从而使参与者感到恐惧。恐惧调节后24小时将参与者扑灭。灭绝后无信号的美国出现后,参与者表现出明显的恐惧恢复。总之,这些程序产生了强大的恐惧增强惊吓,显着的CS + / CS-歧视,会话中的灭绝以及显着的恢复。这是使用令人震惊的措施在人类中消除恐惧和恢复恐惧的第一个证明。

著录项

  • 来源
    《learning_Memory》 |2006年第6期|p.681-685|共5页
  • 作者单位

    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA;

    Atlanta Veterans Affairs Medical Center, Mental Health Service Line 116A, Decatur, Georgia 30033, USA;

    Center for Behavioral Neuroscience, Atlanta, Georgia 30302, USA;

    Department of Psychology, University of Leuven, Tiensestraat 102, B-3000 Leuven, Belgium;

    Social and Behavioral Sciences, University of Amsterdam, Roetersstraat, 1018 WB Amsterdam, The Netherlands;

    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    extinction; reinstatement; human fear-potentiated startle paradigm;

    机译:灭绝;恢复;人类恐惧增强的惊吓范例;
  • 入库时间 2022-08-17 23:32:44

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