Bone Formation Induced by Several Carbonate- and Fluoride-Containing Apatite Implanted in Dog Mandible

摘要

Synthetic hydroxyapatite (HAP), carbonate-apatite (CHA) and carbonate-fluoride-apatite (CFA) were implanted into dog mandible bone for 2, 3, 4, 5 and 6 weeks. The chemical composition and crystallographic properties of the synthetic apatites were examined using FT-IR, TG-DTA, AAS and X-ray diffraction. The comparative resorption in vivo for the experimental period was in the order: CHA CFA > HAP. CHA formed new bone comparable with the sham-control, and CFA induced fast bone-remodeling and newly formed Haversian system. The results confirmed that CHA are potential bone-grafting materials and also showed that CFA, compared to CHA or HAP materials, accelerate bone formation.