Preparation of Silica-Doped Poly(Lactic Acid) Composite Hollow Spheres Containing Calcium Carbonates

摘要

Silica-doped poly(lactic acid) (PLA) composite hollow spheres containing calcium carbonates (Si-CCPC spheres) were prepared using aminopropyltriethoxysilane (APTES) for injectable bone fillers combined with a cell-delivery system. Si-CCPC spheres have a hollow spherical shape of ～1 mm in the external diameter and an open channel in the shell, which is self-formed. The channel size is about 500 μm in diameter. X-ray energy dispersive spectroscopy (EDS) analysis showed incorporation of silicon in Si-CCPC spheres. After soaking Si-CCPC spheres in simulated body fluid (SBF), hydroxycarbonate apatite formed on the Si-CCPC spheres. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) showed that the Si~(4+) ion is released from Si-CCPC spheres in SBF.