Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling

Della-Felice Franco; Sarotti Ariel M.; Krische Michael J.; Pilli Ronaldo A.

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Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling

机译：通过不对称醇介导的羰基还原偶联全合成磷脂二胺A并进行结构验证

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The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.

机译：通过不对称铱催化的醇介导的羰基还原偶联反应，在13个步骤中完成了磷脂酶A的第一个总合成和结构验证。目前的途径是在30种以上的曲霉素家族成员的全部和正式合成中最短的。

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《Journal of the American Chemical Society》 |2019年第35期|13778-13782|共5页
作者
Della-Felice Franco; Sarotti Ariel M.; Krische Michael J.; Pilli Ronaldo A.;
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作者单位

Univ Campinas UNICAMP Inst Chem POB 6154 BR-13083970 Campinas SP Brazil|Univ Texas Austin Dept Chem Austin TX 78712 USA;

Univ Nacl Rosario CONICET Inst Quim Rosario Fac Ciencias Bioquim & Farmaceut Suipacha 531 S2002LRK Rosario Santa Fe Argentina;

Univ Texas Austin Dept Chem Austin TX 78712 USA;

Univ Campinas UNICAMP Inst Chem POB 6154 BR-13083970 Campinas SP Brazil;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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入库时间 2022-08-18 04:58:47

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7. Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling [O] . Franco Della-Felice, Ariel M. Sarotti, Michael J. Krische, 2019

机译：通过不对称醇介导的羰基还原耦合的PhosdieCin A的总合成和结构验证

Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling

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