Supramolecular Design by Covalent Capture. Design of a Peptide Cylinder via Hydrogen-Bond-Promoted Intermolecular Olefin Metathesis

摘要

We have presented a novel approach for the design and synthesis of a covalently stabilized β-sheet-like peptide cylindrical ensemble. The covalent capture strategy presented here is expected to be useful in stabilizing kinetically labile α-helical and β-sheet peptide secondary structures and may also find utility in de novo design of artificial proteins.