Helical β-Peptide Inhibitors of the p53-hDM2 Interaction

摘要

We describe a strategy for the design of protein surface ligands in which a functional epitope is presented by a compact, 14-helical β -peptide scaffold. This strategy may have advantages over one in which individual or multiple β-amino acids are introduced into a functional α-peptide, since it is based on homology of secondary structure, not primary sequence. Currently we are exploring the generality of this strategy and the potencies of β53-1 and β53-5 in vivo.