Rhenium(V)-Catalyzed Synthesis of 2-Deoxy-α-glycosides

摘要

The formation of carbon-heteroatom bonds through acidmediated electrophilic activation of an olefin has a rich history in organic chemistry. The harsh reaction conditions often required for the acid-mediated process prompted the development of alternative strategies involving stoichiometric reagents (Hg~(2+), I~+, PhSe~+) for alkene activation. These methods generate carbonheteroatom bonds from olefins under mild conditions, but suffer from the requirement for a stoichiometric activating reagent and the need for reductive removal from the substrate. A mild catalytic method that allows for addition of nucleophiles to olefins is therefore highly desirable.