Fast Peptidyl cis-trans Isomerization within the Flexible Gly-Rich Flaps of HIV-1 Protease

摘要

Human immunodeficiency virus(HIV),the retrovirus that causes AIDS,infects millions of people around the world.Several drugs have been developed to inhibit the actions of the most common HIV-1 virus by directly targeting its proteolytic machinery.The HIV-1 protease is a homodimer with two flaps controlling access to the active site.The highly conserved flap tips sequence Ile47-Gly-Gly-Ile-Gly-Gly-Phe53 forms a beta-hairpin loop and is known to be flexible.