Direct Asymmetric Zn-Aldol Reaction of Methyl Vinyl Ketone and Its Synthetic Applications

摘要

The aldol reaction is one of the most widely utilized C-C bond-forming reactions in organic chemistry,because of the importance of beta-hydroxy carbonyl compounds in many natural products.Recently,several groups have reported a direct catalytic enanti-oselective version without resorting to preactivation of the pronu-cleophile using biological catalysts and nonbiological transition-metal catalysts,including our own dinuclear Zn complex 2.