• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the American Chemical Society >Turn and Helical Peptide Handedness Governed Exclusively by Side-Chain Chiral Centers
【24h】

Turn and Helical Peptide Handedness Governed Exclusively by Side-Chain Chiral Centers

机译：侧链手性中心独有的转弯和螺旋肽操纵性

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

All protein alpha-amino acids,except Gly,are characterized by an asymmetric alpha-carbon.There is ample evidence in the literature that the configuration at the amino acid a-carbon dictates the preferred handedness of the turns and helices that are formed.In most cases the L configuration preferentially induces right-handed folded structures.Two protein amino acids,Ile and Thr,bear an additional chiral center (at the beta-carbon).To our knowledge,no significant results have been published to date on the conformational effect of Ile (or Thr) side-chain chirality.
机译：除Gly以外的所有蛋白质α-氨基酸均具有不对称的α-碳。在文献中有充分的证据表明，α-碳的氨基酸构型决定了所形成的转弯和螺旋的优选惯性。在大多数情况下，L构型优先诱导右旋折叠结构。两个蛋白质氨基酸，Ile和Thr，具有一个额外的手性中心（在β-碳原子上）。据我们所知，迄今尚未发表有关构象的重大结果Ile（或Thr）侧链手性的影响。

著录项

  • 来源
    《Journal of the American Chemical Society》 |2005年第7期|p.2036-2037|共2页
  • 作者

    Soledad Royo; Wim M.De Borggraeve; Cristina Peggion; Fernando Formaggio; Marco Crisma; Ana I.Jimenez; Carlos Cativiela; Claudio Toniolo;

  • 作者单位

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

    Department of Organic Chemistry,ICMA,University of Zaragoza-CSIC,50009 Zaragoza,Spain,and Institute of Biomolecular Chemistry,CNR,Department of Chemistry,University of Padova,35131 Padova,Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

  • 入库时间 2022-08-18 03:23:46

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号