The Two-State Issue in the Mixed-Valence Binuclear Cu_A Center in Cytochrome c Oxidase and N_2O Reductase

摘要

The binuclear Cu_A site found both in cytochrome c oxidase (CcO) and nitrous oxide reductase (N_2OR) functions in long-range electron transfer (ET).Studies of Cu_A sites have been facilitated by the construction of inorganic models and the perturbation of Cu_A sites by mutation and by inserting Cu_A into proteins containing cupredoxin folds.