Imaging Farnesyl Protein Transferase Using a Topologically Activated Probe

摘要

Ras proteins play important roles in cell signal transduction,including the cell division cycle,programmed cell death,and differentiation.In addition,Ras proteins are also responsible for about 30% of all human carcinomas,including 90% of pancreatic,50% of colon,and 30% of lungand breast cancers.The proteins must be localized to the inner surface of the plasma membrane to be biologically active in all of these events.