The Hydrogenation/Transfer Hydrogenation Network: Asymmetric Hydrogenation of Ketones with Chiral eta~6-Arene/N-Tosylethylenediamine-Ruthenium(II) Catalysts

摘要

Asymmetric transfer hydrogenation (ATH) with organic reducing agents catalyzed by transition metal complexes is mechanistically linked with asymmetric hydrogenation (AH) using molecular hydrogen because both reactions commonly involve metal hydride species.However,most of the existing chiral catalysts are effective for only one of these reactions.We have long conjectured that certain chiral metal complexes can be made to catalyze both ATH and AH by switching reaction parameters so that the conditions can tolerate acid/base-sensitive substrates.