Synthesis of Indoles via 6π-Eiectrocyclic Ring Closures of Trienecarbamates

摘要

We have shown that both of the aromatic rings of indoles can be constructed from readily available α-haloenones and α-(trialkylstannyl)enecarbamates using a five-step reaction sequence that features facile electrocyclic ring closures of trienecarbamates. The method may prove to be most useful for the preparation of indoles possessing complex or difficult substitution patterns. The syntheses of natural products of this type are underway.