Ladder Polyether Synthesis via Epoxide-Opening Cascades Using a Disappearing Directing Group

摘要

The ladder polyether natural products (Figure 1) are associated with a number of marine phenomena,including the Red Tide.Twenty years ago,Nakanishi proposed an intriguing explanation for the structural and stereochemical similarities found in all known members of this family-the transformation of a polyepoxide into a ladder polyether via a cascade of epoxide-opening events.