Total Synthesis of (-)-Pseudolaric Acid B

摘要

Pseudolaric acids B and A (la and lb, Scheme 1) are diterpene acids isolated from the extract of the root bark of Pseudolarix kaempferi Gordon (pinaceae), which is also used in tujinpi, a traditional Chinese medicine for the treatment of fungal infections of the skin and nails. Pseudolaric acid B (la) has been identified as a potent antifungal, antifertility, and cytotoxic agent, displaying much higher activity than pseudolaric acid A (lb). More recently, the discovery that pseudolaric acid B (la) displays significant activity against multidrug resistant cancer cell lines has revitalized interest in this natural product.