Mild Reductive Opening of Aryl Pyranosides Promoted by Scandium(III) Triflate

摘要

An efficient method for the nucleophilic ring opening of stereochemically well-defined aryl pyranosides is presented. The reaction effects a formal deoxygenation of the benzylic position to provide useful, enantioenriched, building blocks. Future work will include further determination of the reaction scope and application of the present methodology in natural product synthesis.