Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function

摘要

The bryostatins are a family of complex macrolactone natural products, originally isolated from the marine bryozoan Bugula neritina by Pettit and co-workers. Bryostatin 1(1, Figure 1) has shown promising anticancer activity that has led to some 80 clinica