Asymmetric Organocatalytic Three-Component 1,3-Dipolar Cycloaddition: Control of Stereochemistry via a Chiral Bronsted Acid Activated Dipole

摘要

1,3-Dipolar cycloaddition of azomethine ylide to electron-deficient olefins yields chiral pyrrolidines, an important class of heterocyclic compounds with widespread applications to the synthesis of biologically active compounds and natural products.1 Thes