A Chirat Bis-Sulfoxide Ligand in Late-Transition Metal Catalysis; Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Electron-Deficient Olefins

摘要

Asymmetric metal catalysis has seen tremendous developments in the last decades. The overwhelming majority of successful chiral chelate ligands in late-transition metal catalysis are based on phosphorus and/or nitrogen. Recently, Hayashi and Carreira have developed alternative chiral diene ligands for asymmetric rhodium and iridium catalysis. Synthesis of these new dienes as well as the more traditional P/N ligands requires multistep synthetic procedures with often tedious separation of the enantiomers.- A potentially very readily available chiral ligand class with a well-known coordination chemistry is represented by sulfoxides.