Anthracycline Chemistry and Biology I: Biological Occurrence and Biosynthesis, Synthesis and Chemistry

摘要

This book, Volume 282 of the renowned series Topics in Current Chemistry, covers many different aspects of the origin, chemistry, and biosynthesis of one of the oldest but most important classes of anticancer agents. Daunorubicin and doxorubicin, the prototype agents of the anthracyclines, have become the key components of curative regimens for multiple human neoplasms, demonstrating the clinical utility of this classrnof compounds. In addition to these drugs, epirubicin and idarubicin are also in clinical use, and there are several new analogues in preclinical and clinical development. Arguably, doxorubicin is the most recognized and representative member of this class of drugs and is also a molecule of choice for numerous biological studies, including understanding its mechanism of action, synthesis of new analogues, and investigation of its combination with different targeted therapies and delivery systems. This book is an important update on the field, which was last reviewed comprehensively in 1995.