Enantioselective α-Benzylation of Aldehydes via Photoredox Organocatalysis

摘要

The first enantioselective aldehyde α-benzylation using electron-deficient aryl and heteroaryl substrates has been ac-complished. The productive merger of a chiral imidazolidinone organocatalyst and a commercially available iridium photoredox catalyst in the presence of household fluorescent light directly affords the desired homobenzylic stereogenicity in good to excellent yield and enantioselectivity. The utility of this methodol-ogy has been demonstrated via rapid access to an enantioen-riched drug target for angiogenesis suppression.