Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me_3SiCF_3

摘要

Trifluoromethylated compounds are of particular interest in the fields of polymers, agrochemicals, and Pharmaceuticals due to the unique characteristics of the trifluoromethyl group (-CF_3), such as high electronegativity, electron density, steric hindrance, and hydrophobicity. Hence, it has been of great synthetic interest to develop an efficient method for incorporation of CF_3 into organic structures.