Highly Diastereoselective Preparation of Homoallylic Alcohols Containing Two Contiguous Quaternary Stereocenters in Acyclic Systems from Simple Terminal Alkynes

摘要

The stereoselective synthesis of quaternary stereocenters in an acyclic system is one of the major challenges in asymmetric synthesis. Although many new elegant synthetic strategies were developed in the past few years, mostly through asymmetric catalysis, a single carbon-carbon bond is usually created per chemical step. We have recently considered a different approach to prepare such stereocenters in an acyclic system in which several carbon-carbon bonds could be formed in a single-pot operation via the use of ambiphilic zinc carbenoid species.