Nickel-Mediated Oxidative Fluorination for PET with Aqueous [~(18)F] Fluoride

Eunsung Lee; Jacob M. Hooker; Tobias Ritter

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Nickel-Mediated Oxidative Fluorination for PET with Aqueous [~(18)F] Fluoride

机译：镍介导的[〜（18）F]氟化物对PET的氧化氟化

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摘要

A one-step oxidative fluorination for carbon-fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical ~(18)F late-stage fluorination of complex small molecules with potential for PET imaging.

机译：提出了一种通过明确定义的镍配合物与氧化剂和氟化物水溶液形成碳-氟键的一步氧化氟化方法，该方法可实现复杂小分子的直接且实用的〜（18）F后期氟化，具有PET成像的潜力。

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《Journal of the American Chemical Society》 |2012年第42期|17456-17458|共3页
作者
Eunsung Lee; Jacob M. Hooker; Tobias Ritter;
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作者单位

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States;

Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown,Massachusetts 02129, United States,Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States;

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States,Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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入库时间 2022-08-18 03:13:38

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Nickel-Mediated Oxidative Fluorination for PET with Aqueous [~(18)F] Fluoride

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