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机译:通过改变HIV-1蛋白酶的动态和结构集合,通过活动位点外部突变赋予的耐药性。
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States;
机译:探讨CRF01_AE HIV-1蛋白酶的活性位点,非活性位点突变及其合作效应的耐药机制:分子动力学模拟和自由能计算
机译:一组非活动位点突变在开发HIV-1蛋白酶耐药性中的主要作用。
机译:HIV-1蛋白酶非活性位点突变V77I引起的奈非那韦耐药分子机制的结构研究
机译:乙酰辅酶A羧化酶活性位点W374C突变的结构作用的计算机模拟:多药耐药机制
机译:多药耐药HIV-1蛋白酶的晶体学,分子动力学和酶学研究及其对基于结构的药物设计的启示(项目1);人髓磷脂蛋白零的晶体学研究(项目2)。
机译:耐药性由外部的突变赋予通过改变动态和结构整体来激活活动场所HIV-1蛋白酶的数量
机译:通过HIV-1蛋白酶的动态和结构集合的改变,由活性位点外的突变赋予的耐药性