A simple and efficient procedure for synthesis of optically active 1,2-bis(s-triazolo (Bis (S-triazolo[3,4-b][1,3,4]thiadiazole-3-yl) alkane derivatives containing L-amino acid moieties

摘要

A series of 1,2-bis(s-triazolo (Bis (S-triazolo[3,4-b][1,3,4]thiadiazolo-3-yl)alkanes 3a-3k were prepared by condensation reaction of 1,2-bis(4-amino-5-mercapto-S-triazol-3-yl)alkanes 1a-1c with N-phetaloyl-l-amino acids 2a-2d in the presence of the phosphoroxy chloride (POCl₃) as an anhydrous reagent.