Study of inclusion complexes of valsartan with β-cyclodextrin and hydroxypropyl β-cyclodextrin

摘要

This study presents improvement in solubility and dissolution rate of valsartan (VAL) using β-cyclodextrin (PCD) and hydroxypropyl-βVcyclodextrin (HP-βCD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTTR, SEM, ~1HNMR and in-vitro dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-evaporation method showed higher in vitro drug dissolution rates.