New SPE column packing material: Retention assessment method and its application for the radionuclide chromatographic separation

摘要

The preparation of the OASIS®-HLB sorbent based solid phase extraction (SPE) resins and their application for the 177Lu radioisotope separation were investigated. Di-(2-ethylhexyl) orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP) were successfully developed from this investigation. The wettable porosity structure of the moderately extractant impregnated OASIS-HDEHP resins is favorable for the effective diffusion of polar and ionic solutes giving good separation performance. Its good wetting ability offers ease of packing into conventional chromatographic columns. Their off-gassing-free operation makes OASIS-HDEHP columns good for long term use with highly consistent elution dynamics (several dozens of separations perfectly achievable on the same column). The simple method for the capacity factor (k’) evaluation was developed to facilitate the characterization of the SPE chromatographic resin column. A competent procedure using OASIS-E30RS resin (one member of the OASIS-HDEHP resin group) for the separation of no-carrier added (n.c.a) 177Lu from the bulk amount of Yb target was developed. This separation procedure has showed very good performance with several prominent advantages such as the much shorter separation time (5–6 hours) and high reproducibility. Its high adsorption capacity for Yb and Lu makes it ideal for the separation of the bulky sample (50 mg Yb target for the 20 g weight resin column) for the production of the several Ci of 177Lu radioactivity.