A tandem generator system for production of 223Ra and 211Pb/211Bi in DTPA solutions suitable for potential application in radiotherapy

摘要

A simple and effective tandem generator system (anion- and cation-exchange columns connected successively) on production of 223Ra and 211Pb/211Bi in DTPA solutions suitable for biomedical studies has been developed. 223Ra was repeatedly separated from parent radionuclides 227Ac and 227Th, sorbed on anion-exchange column (generator 1), and is loaded directly on cation-exchange column (generator 2) from HNO₃/CH₃OH solutions. Cation-exchange behavior of Ra and Pb in DTPA solutions was studied in detail. Optimum conditions have been found for repeated isolation of 211Pb/211Bi and 223Ra in form of chelate complexes with DTPA from cation-exchange column (generator 2). The decontamination factor of short-lived descendants from parent radionuclides was ≥106. The system is reliable and easy to use. The advantages of tandem generator system for application in radiotherapy are discussed.