Siamyl glyoxylate as an efficient enophile in the Lewis acid mediated glyoxylate ene-reaction with allylic ethers. Application to the synthesis of a taxol a-ring subunit

摘要

In contrast to other simple alkyl glyoxylates, siamyl glyoxylate (1a) proved to be an effective enophile in the glyoxylate ene-reaction with the allylic ether 2a, which we earlier used for the synthesis of the A-ring subunit of taxol.