How many NOE derived restraints are necessary for a reliable determination of the relative configuration of an organic compound? Application to a model system

摘要

The determination of the relative and absolute config- uration of natural products is essential to understand their biological activity. In synthetic organic chemistry, the knowledge of the stereochemistry of intermediates is necessary to understand stereoselective reactions. Presently, the standard methods for determining the Relative or absolute configuration of organic compounds Are X-ray crystallography, chemical synthesis, and NMR Spectroscopy.