Novel chiral recognition in host-guest inclusion complexes depends on their molar ratios: efficientresolution of 2,2'-dihydroxy-1,1'-biphenyl derivatives and CD spectral study of inclusion complex crystals

摘要

It is known that optically acitive 2,2'-dihydroxy-1,1'- binaphthyl (1) is useful not only as a key compound in the preparation of chiral catalysts for asymmetric syn- thesis but also as a chiral shift reagent and as a chiral host compound for the optical resolution of guest com- pounds. The axially-chiral 2,2'-dihydroxy-1,1'-biphenyl derivatives 2 and 3 are also expected to behave in a similar fashion and, indeed, may have advantages as chiral ligands in catalysts for asymmetric synthesis because of their much simpler structures.