Convenient deuteration of bromo aromatic compounds by reductive debromination with sodium amalgam in

摘要

Deuterated compounds provide conclusive information on the proton assignments of H NMR and ESR spectra and play important roles in kinetic and mechanism studies and in the biochemical field. However, the desired deuterated compounds, particularly partly deu- terated compounds, with high isotopic purities are still difficult to prepare and require many steps in their preparation, starting from commercially available, but expensive deuterated compounds.