Cobalt-mediated aldol-type reactions

摘要

We have already reported that a Co(0)-trimethylphos- phine complex is an efficient mediator for one-pot Refor- matsky-type reactions of halogen derivatives with car- bonyl compounds to give secondary and tertiary alcohols. The investigation was extended to other low-oxidation- State cobalt complexes, which have also proven effective, With several advantages over the classical zinc-mediated Reformatsky reaction, the most notable being the milder Conditions and the higher yields of addition products.