HYCRON, an allylic anchor for high-efficiency solid phase synthesis of protected peptides and glycopeptides

摘要

The recently developed allylic HYCRON anchor exhibits excellent properties for the solid phase weight compounds assessed the acid- and glycopeptides. Model reactions with analogous low molecular weight compounds assessed the acid- and base-stability of the polar and flexible HYCRON linkage. The new anchor is available in a two-step synthesis and allows the use of both the Boc- and the Fmoc-strategy, which can even be combined within one synthesis.