Transition metal-mediated stereocontrolled cyclization of urethanes leading to versatile fused piperidines and its application to the synthesis of (+)-prosopinine and (+)-palustrine

摘要

Streoselective amino cycloaddition of alkenylamines is one of the most important approaches for the stereo- selective construction of nitrogen heteroalicycles, which form the skeletons of several biologically active natural products and related compounds. Palladium(0)-catalyzed allyic substitution in particular provides efficient ste- reoselective C-N bond formation.