Novel synthesis of 3,6-disubstituted 1,2-dithiin molecules involving a direct oxidative deprotection-cyclization sequence from 1.4-bis(tert-butylthio)- 1,3-butadiene precursors

摘要

Over a dozen 1,2-dithiin (1) (1,5-dithia-3,5-cyclohexa- diene)-containing natural products have been isolated primarily from the leaves and roots of the plants belong- ing to the Asteraceae genus.~1 Interestingly, all of these naturally occurring 1,2-dithiins isolated thus far contain acetylene and polyacetylene side chains at the C-3 and C-6 positions of the 8π, anti-aromatic 1,2-dithiin ring System~2 (see, e.g., thiarubrine A (2)).