Nucleic Acid Related Compounds. 87. Nucleophilic Function all zation of Cytidine and 2'-Deoxycytidine Derivatives via Elaboration of the 4-Amino Group into a Readily Displaced l,2,4-Triazol-4-yl Substituent

摘要

Nucleosides which contain subutituents on the hetero-cyclic base other than the natural oxo and amino functionalities are important compounds for medicinal chemistry and biological studies. A common methodology for synthesis of such compounds involvesmodification/ displacement of a natural functional group by a nucleo-phile. Established procedures are available for conversion of pyrimidine 4 and purine 6-oxo functionalities into alkoxy, chloro, pyridinium, silyloxy, and sulfur leaving groups. However, few methods have been described for accomplishing analogous transformations beginning with an amino group, and these are generally inconvenient.