首页> 外文期刊>The Journal of Organic Chemistry >Enantioselective Synthesis of 3,3-Disubstituted Piperidine Derivatives by Enolate Dialkylation of Phenylglycinol-Derived Oxazolopiperidone Lactams
【24h】

Enantioselective Synthesis of 3,3-Disubstituted Piperidine Derivatives by Enolate Dialkylation of Phenylglycinol-Derived Oxazolopiperidone Lactams

机译:对苯二甘醇衍生的恶唑并哌啶酮内酰胺的戊二酸酯的二烷基化对映选择性合成3,3-二取代的哌啶衍生物

获取原文
获取原文并翻译 | 示例
       

摘要

The stereochemical outcome of the enolate dialkylation of simple phenylglycinol-derived oxazolopiperidone lactams is studied. High stereoselectivities in the generation of the quaternary stereocenter are obtained by the appropriate choice of both the configuration of the starting lactam and the order of introduction of the substituents. The usefulness of the methodology is illustrated by the conversion of some of the dialkylated lactams into known synthetic precursors of alkaloids and by the total synthesis of (-)-quebrachamine.
机译:研究了简单的苯基甘醇衍生的恶唑并哌啶酮内酰胺的烯醇二烷基化的立体化学结果。通过适当选择起始内酰胺的构型和取代基的引入顺序,可以在四元立体中心的生成中获得高立体选择性。通过将一些二烷基化内酰胺转化为已知的生物碱合成前体以及通过全合成(-)-quebrachamine可以说明该方法的实用性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号