Acid-Catalyzed Aza-Diels—Alder Reactions for the Total Synthesis of (±)-Lapatin B

摘要

A 5-step total synthesis of microfungal alkaloid (±)-lapatin B has been accomplished via a key 2-aza-Diels—Alder reaction. Br0nsted acids catalyze the cycloaddition step and provide improved exo selectivity. This synthetic route has been applied to the construction of related spiro-quinazoline structures.