Two-Fold Modification of the Phenyl Substituent in Phenylphosphonic Acid Monoester Monoamides

摘要

Phenylphosphonic acid ethyl ester N,N-diethylamide was subjected to a double modification of its phenylnsubstituent through directed ortho-metalation followed by dearomatization of the aryl substituent under Birch reductionnconditions. Application of the same methodology to a diastereomerically pure phenylphosphonic acid monoester monoamide lednto the formation of P-stereogenic cyclohexadienyl-phosphonic acid derivatives. The method offers a simple and efficientnmodification of phenyl substituent in organophosphorus compounds.