Metal Cocatalyzed Tandem Alkynylative Cyclization Reaction of in Situ Formed N?Iminoisoquinolinium Ylides with Bromoalkynes via C?H Bond Activation

摘要

Silver triflate and copper(I) iodide cocatalyzedndirect alkynylation and cyclization reaction of in situ formednN-iminoisoquinolinium ylides with bromoalkynes is described.nThe reaction proceeds efficiently through a combination ofnC−H activation and subsequent tandem reaction in one pot,nleading to diverse H-pyrazolo[5,1-a]isoquinolines in goodnyields under mild reaction conditions.